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In the hippocampus, cell assemblies forming mnemonic representations of space are thought to arise as a result of changes in functional connections of pyramidal cells. We have found that CA1 interneuron circuits are also reconfigured during goal-oriented spatial learning through modification of inputs from pyramidal cells. As learning progressed, new pyramidal assemblies expressed in theta cycles alternated with previously established ones, and eventually overtook them. The firing patterns of interneurons developed a relationship to new, learning-related assemblies: some interneurons associated their activity with new pyramidal assemblies while some others dissociated from them. These firing associations were explained by changes in the weight of monosynaptic inputs received by interneurons from new pyramidal assemblies, as these predicted the associational changes. Spatial learning thus engages circuit modifications in the hippocampus that incorporate a redistribution of inhibitory activity that might assist in the segregation of competing pyramidal cell assembly patterns in space and time.

Original publication

DOI

10.1016/j.neuron.2013.01.033

Type

Journal article

Journal

Neuron

Publication Date

10/04/2013

Volume

78

Pages

166 - 180

Keywords

Action Potentials, Animals, Brain Mapping, Brain Waves, Cues, Hippocampus, Interneurons, Learning, Male, Maze Learning, Models, Neurological, Nerve Net, Neuronal Plasticity, Nonlinear Dynamics, Probability, Rats, Rats, Long-Evans, Space Perception