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We report the cDNA sequence and expression of a mouse homeobox gene, Dmbx1, from the PRD class and comparison to its human orthologue. The gene defines a new homeobox gene family, Dmbx, phylogenetically distinct from the Ptx, Alx, Prx Otx, Gsc, Otp and Pax gene families. The Dmbx1 gene is expressed in the developing mouse diencephalon, midbrain and hindbrain, and has dynamic expression during forelimb and hindlimb development. Unusually for homeobox genes, there is no orthologue in the Drosophila or Caenorhabditis genomes; we argue this reflects secondary loss.

Original publication




Journal article


Dev Genes Evol

Publication Date





293 - 297


Amino Acid Sequence, Animals, Brain, Extremities, Gene Expression Regulation, Developmental, Homeodomain Proteins, Humans, In Situ Hybridization, Mice, Molecular Sequence Data, Nerve Tissue Proteins, Otx Transcription Factors, Phylogeny, RNA, Messenger, Sequence Homology, Amino Acid