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Aminoacyl-tRNA (AA-tRNA) formation is a key step in protein biosynthesis. This reaction is catalyzed with remarkable accuracy by the AA-tRNA synthetases, a family of 20 evolutionarily conserved enzymes. The lack of cysteinyl-tRNA (Cys-tRNA) synthetase in some archaea gave rise to the discovery of the archaeal prolyl-tRNA (Pro-tRNA) synthetase, an enzyme capable of synthesizing Pro-tRNA and Cys-tRNA. Here we review our current knowledge of this fascinating process.

Type

Journal article

Journal

FEBS Lett

Publication Date

06/03/2002

Volume

514

Pages

34 - 36

Keywords

Non-programmatic, Amino Acyl-tRNA Synthetases, Cysteine, Methanococcus, Proline, Protein Biosynthesis, RNA, Transfer, RNA, Transfer, Amino Acyl