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Four PLS patients underwent cerebral [(11)C]-flumazenil PET. They were compared firstly with a group of controls, then later directly with a group of sporadic ALS patients and a familial ALS group homozygous for the 'D90A' SOD1 gene mutation. There was a similar pattern of decreased binding in PLS patients when compared to controls as that seen in a previous study of sporadic ALS patients, supporting the concept that PLS is part of the same overall spectrum of MND. However, in direct group comparisons, both sporadic and homD90A ALS patients demonstrated relative decreases in anterior and orbito-frontal binding compared to PLS patients, suggesting that there may be differences in cortical vulnerability between phenotypic groups.

Original publication

DOI

10.1007/s00415-006-0482-7

Type

Journal article

Journal

J Neurol

Publication Date

08/2007

Volume

254

Pages

1033 - 1036

Keywords

Adult, Aged, Carbon Isotopes, Cerebral Cortex, Female, Humans, Male, Middle Aged, Motor Neuron Disease, Positron-Emission Tomography