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Congenital myasthenic syndromes (CMS) are a group of inherited disorders that arise from impaired signal transmission at the neuromuscular synapse. They are characterized by fatigable muscle weakness. This is a heterogenous group of disorders with 15 different genes implicated in the development of the disease. Using whole-exome sequencing we identified DPAGT1 as a new gene associated with CMS. DPAGT1 catalyses the first step of N-linked protein glycosylation. DPAGT1 patients are characterized by weakness of limb muscles, response to treatment with cholinesterase inhibitors, and the presence of tubular aggregates on muscle biopsy. We showed that DPAGT1 is required for glycosylation of acetylcholine receptor (AChR) subunits and efficient export of AChR to the cell surface. We suggest that the primary pathogenic mechanism of DPAGT1-associated CMS is reduced levels of AChRs at the endplate region. This finding demonstrates that impairment of the N-linked glycosylation pathway can lead to the development of CMS.

Original publication

DOI

10.1111/j.1749-6632.2012.06790.x

Type

Journal article

Journal

Ann N Y Acad Sci

Publication Date

12/2012

Volume

1275

Pages

29 - 35

Keywords

Amino Acid Sequence, Animals, Humans, Molecular Sequence Data, Mutation, Myasthenic Syndromes, Congenital, Neuromuscular Junction, Sequence Homology, Amino Acid, Transferases (Other Substituted Phosphate Groups)