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Mapping gene regulatory networks is a significant challenge in systems biology, yet only a few methods are currently capable of systems-level identification of transcription factors (TFs) that bind a specific regulatory element. We developed a microfluidic method for integrated systems-level interaction mapping of TF-DNA interactions, generating and interrogating an array of 423 full-length Drosophila TFs. With integrated systems-level interaction mapping, it is now possible to rapidly and quantitatively map gene regulatory networks of higher eukaryotes.

Original publication




Journal article


Nucleic Acids Res

Publication Date





Animals, Base Sequence, Consensus Sequence, DNA, Drosophila melanogaster, Gene Library, Gene Regulatory Networks, Microfluidic Analytical Techniques, Nucleotide Motifs, Position-Specific Scoring Matrices, Regulatory Elements, Transcriptional, Transcription Factors