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The presence of oligoclonal bands of IgG (OCB) in cerebrospinal fluid (CSF) is used to establish a diagnosis of multiple sclerosis (MS), but their specificity has remained an enigma since its first description over forty years ago. We now report that the use of lipid arrays identifies heteromeric complexes of myelin derived lipids as a prominent target for this intrathecal B cell response.

Original publication




Journal article


J Neuroimmunol

Publication Date





87 - 95


Analysis of Variance, Animals, B-Lymphocytes, Cells, Cultured, Embryo, Mammalian, Humans, Immunoglobulin G, Lipid Metabolism, Multiple Sclerosis, Myelin Basic Protein, Myelin Sheath, O Antigens, Oligoclonal Bands, Rats, Rats, Sprague-Dawley, Spinal Cord