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Understanding the basis of epigenetic memory is a fast-moving challenge in modern biology. At a recent Company of Biologists Workshop held at Steyning's historic Wiston House, thirty researchers led by John Gurdon interrogated three central questions: how are cell type-specific programs generated, what mechanisms duplicate this programmatic information as cells divide, and how does epigenetics contribute to trans-generational inheritance? We report some of the emerging themes arising from this debate.

Original publication

DOI

10.1242/dev.084434

Type

Journal article

Journal

Development

Publication Date

11/2012

Volume

139

Pages

3891 - 3896

Keywords

Animals, Centromere, Chromatin, Congresses as Topic, Epigenesis, Genetic, Heredity, Humans, Mitosis, Models, Biological