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Drosophila Rhomboid-1 was discovered to be the first known intramembrane serine protease about 7 years ago. The study of the rhomboid-like family has since blossomed, and the purpose of this review is to take stock of where the field is, and how it may progress in the next few years. Three major themes are the increasing understanding of the biological roles of rhomboids, the detailed information we now have about their function and mechanism, and the promising leads they offer as medical targets.

Original publication




Journal article


Semin Cell Dev Biol

Publication Date





231 - 239


Animals, Humans, Membrane Proteins, Mitochondria, Models, Biological, Models, Molecular, Receptor, Epidermal Growth Factor