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Genome-wide association studies (GWASs) have transformed the field of human genetics and have led to the discovery of hundreds of genes that are implicated in human disease. The technological advances that drove this revolution are now poised to transform genetic studies in model organisms, including mice. However, the design of GWASs in mouse strains is fundamentally different from the design of human GWASs, creating new challenges and opportunities. This Review gives an overview of the novel study designs for mouse GWASs, which dramatically improve both the statistical power and resolution compared to classical gene-mapping approaches.

Original publication

DOI

10.1038/nrg3335

Type

Journal article

Journal

Nat Rev Genet

Publication Date

11/2012

Volume

13

Pages

807 - 817

Keywords

Animals, Breeding, Chromosome Mapping, Chromosomes, Mammalian, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Male, Mice, Research Design