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A necropsy study of 159 elderly patients drawn mainly from a prospectively assessed geriatric hospital population was carried out to investigate the relationship of cerebral amyloid angiopathy to Alzheimer's disease, other CNS disease and ageing. About half the patients were demented and the majority of these had Alzheimer's disease. In Alzheimer's disease there was an incidence of cerebral amyloid angiopathy of 82%. Among the other groups of patients, both demented and non-demented, the incidence of cerebral amyloid angiopathy was a little over 30%, and remained constant between 60 and 102 years of age.

Original publication




Journal article


J Neurol Neurosurg Psychiatry

Publication Date





1221 - 1226


Aged, Aged, 80 and over, Alzheimer Disease, Amyloid, Amyloidosis, Blood Vessels, Brain, Cerebral Infarction, Cerebrovascular Disorders, Congo Red, Female, Histocytochemistry, Humans, Male, Middle Aged