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Stiff-person syndrome (SPS) is a rare condition of progressive muscular rigidity and spasm, frequently accompanied by other autoimmune conditions, an association which has been further strengthened by the discovery of anti-GAD antibodies and the response of SPS to immunotherapies. Intravenous immunoglobulin (IVIg) is the mainstay therapy. Because of the rarity of the GAD antibody associated conditions, most of the information regarding treatment is case series and individual case reports. Here we describe the 15 year long management of a subject with SPS who has had a favourable outcome.

Original publication




Journal article


J Neurol

Publication Date





1898 - 1900


Humans, Immunoglobulins, Intravenous, Immunosuppressive Agents, Male, Middle Aged, Stiff-Person Syndrome