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Serum antibodies to muscle-specific receptor tyrosine kinase were detected in 12 of 32 patients with generalized seronegative MG. All were women, with onset between ages 21 and 59 years. Seven had prominent neck, shoulder, or respiratory muscle weakness and little or delayed ocular muscle involvement. The response to cholinesterase inhibitors was variable, and electromyographic findings suggested myopathy in several. None improved after thymectomy. All patients improved after plasma exchange, and most had a good response to selected immunotherapy. MuSK antibody status should help diagnose MG with atypical presentations and ensure appropriate patient treatment.

Type

Journal article

Journal

Neurology

Publication Date

24/06/2003

Volume

60

Pages

1978 - 1980

Keywords

Adult, Autoantibodies, Autoantigens, Combined Modality Therapy, Electromyography, Female, Humans, Immunosuppressive Agents, Middle Aged, Myasthenia Gravis, Neural Conduction, Organ Specificity, Plasma Exchange, Receptor Protein-Tyrosine Kinases, Receptors, Cholinergic, Single-Blind Method, Thymectomy, Treatment Outcome