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Several reports from Western countries suggest differences in the clinical features of patients with muscle specific kinase (MuSK) antibody-positive and -negative seronegative myasthenia gravis (MG). We performed the first survey in Korea of MuSK antibodies, studying 23 patients with acetylcholine receptor (AChR)-antibody seronegative MG. MuSK antibodies were present in 4 (26.7%) of 15 generalized seronegative MG patients and none of 8 ocular seronegative MG patients. All four MuSK positive patients were females, with pharyngeal and respiratory muscle weakness, and required immunosuppressive treatment. However, overall disease severity and age at onset was similar to that of MuSK-negative MG and treatment responses were equally good.

Original publication

DOI

10.1016/j.jocn.2005.04.028

Type

Journal article

Journal

J Clin Neurosci

Publication Date

04/2006

Volume

13

Pages

353 - 355

Keywords

Adolescent, Adult, Age of Onset, Antibodies, Child, Child, Preschool, Female, Humans, Immunosuppressive Agents, Infant, Korea, Male, Middle Aged, Myasthenia Gravis, Receptor Protein-Tyrosine Kinases, Receptors, Cholinergic, Severity of Illness Index, Thymectomy