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Opsoclonus-myoclonus syndrome (OMS) in children is a rare disorder including a severe eye movement disturbance, myoclonia, ataxia and often developmental retardation. Both OMS forms, idiopathic or neuroblastoma-associated (paraneoplastic), have been suspected to be autoimmune. Recently, autoantibodies have been found in OMS sera. We here show that autoantibodies in OMS, both intracellular and surface binding, belong mainly to the IgG3 subclass, although the total serum IgG3 level is normal. These results support the autoimmune hypothesis and point to a protein autoantigen as antigenic target.

Original publication

DOI

10.1016/j.jneuroim.2007.01.006

Type

Journal article

Journal

J Neuroimmunol

Publication Date

04/2007

Volume

185

Pages

145 - 149

Keywords

Animals, Autoantibodies, Autoantigens, Blotting, Western, Child, Female, Flow Cytometry, Humans, Immunoglobulin G, Immunohistochemistry, Infant, Male, Opsoclonus-Myoclonus Syndrome, Rats