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We review the latest literature on the neuropharmacological treatments for acquired nystagmus.Nystagmus may have a significant [corrected] impact on health, yet there is little scientific evidence on which to make firm recommendations for treatment. Acquired pendular nystagmus may respond to gabapentin or memantine; downbeat and upbeat nystagmus to aminopyridines; and periodic alternating nystagmus to baclofen. To improve treatment we need multi-centre, randomised controlled trials using standardised techniques in reporting objective outcomes, with good follow-up duration and careful reporting of side effects.

Original publication




Journal article


Pract Neurol

Publication Date





147 - 153


Amines, Aminopyridines, Baclofen, Cyclohexanecarboxylic Acids, Humans, Memantine, Nystagmus, Congenital, Nystagmus, Pathologic, Randomized Controlled Trials as Topic, Treatment Outcome, gamma-Aminobutyric Acid