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SMA-Lipodisq nanoparticles, with one bacteriorhodopsin (bR) per 12 nm particle on average (protein/lipid molar ratio, 1:172), were prepared without the use of detergents. Using pulsed and continuous wave nitroxide spin label electron paramagnetic resonance, the structural and dynamic integrity of bR was retained when compared with data for bR obtained in the native membrane and in detergents and then with crystal data. This indicates the potential of Lipodisq nanoparticles as a useful membrane mimetic.

Original publication

DOI

10.1021/nl3020395

Type

Journal article

Journal

Nano Lett

Publication Date

12/09/2012

Volume

12

Pages

4687 - 4692

Keywords

Bacteriorhodopsins, Biomimetic Materials, Crystallization, Detergents, Lipids, Macromolecular Substances, Materials Testing, Molecular Conformation, Nanostructures, Particle Size, Surface Properties