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The identification of human quantitative trait genes underlying variation in emotionality has proved to be both difficult and expensive. Whilst several QTL have been consistently identified and independently replicated across both phenotypes and populations, little progression has been made towards the identification of underlying genes or even variants. In this review we discuss the potential for using cross-species QTL concordance as a tool for QTL dissection in behaviour genetics, using an affect-related locus mapped to human chromosome 1 as an example.

Original publication

DOI

10.1016/j.neubiorev.2006.07.006

Type

Journal article

Journal

Neurosci Biobehav Rev

Publication Date

2007

Volume

31

Pages

115 - 124

Keywords

Animals, Chromosome Mapping, Chromosomes, Human, Pair 1, Emotions, Genetic Variation, Genetics, Behavioral, Humans, Lod Score, Models, Animal, Phenotype, Quantitative Trait Loci, Quantitative Trait, Heritable