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Unusually for an RNA virus, influenza A viruses transcribe and replicate their genomes in the nuclei of infected cells. As a result the viral ribonucleoprotein complexes (RNPs), and their newly synthesised protein subunits, must interact with the host nuclear import machinery. In this review we discuss how the virus exploits nuclear import pathways to allow regulated and chaperoned assembly of RNPs in the nucleus, and describe how the import machinery itself can be a determinant of host tropism.

Original publication

DOI

10.1016/j.vaccine.2012.04.085

Type

Journal article

Journal

Vaccine

Publication Date

07/12/2012

Volume

30

Pages

7353 - 7358

Keywords

Active Transport, Cell Nucleus, Cell Nucleus, Influenza A virus, Models, Biological, RNA, Viral, Viral Proteins, Virus Replication