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Adult hippocampal neurogenesis is a unique example of structural plasticity, the functional role of which has been a matter of intense debate. New transgenic models have recently shown that neurogenesis participates in hippocampus-mediated learning. Here, we show that transgenic animals, in which adult hippocampal neurogenesis has been specifically impaired, exhibit a striking increase in anxiety-related behaviors. Our results indicate that neurogenesis plays an important role in the regulation of affective states and could be the target of new treatments for anxiety disorders.

Original publication

DOI

10.1038/mp.2009.15

Type

Journal article

Journal

Mol Psychiatry

Publication Date

10/2009

Volume

14

Pages

959 - 967

Keywords

Animals, Anxiety, Behavior, Animal, Cell Count, Chlordiazepoxide, Depression, Doxycycline, Hippocampus, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Neurogenesis, Neurons, bcl-2-Associated X Protein