Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

During adulthood, new neurons are continuously added to the mammalian dentate gyrus (DG). An increasing number of studies have correlated changes in rates of dentate neurogenesis with memory abilities. One study based on subchronic treatment with the toxin methylazoxymethanol acetate (MAM) has provided causal evidence that neurogenesis is involved in hippocampal-dependent trace conditioning. In contrast, spatial learning is not impaired following MAM treatment. We hypothesized that this was due to the small residual number of new cells produced following MAM treatment. In the present experiment, we attempted to achieve a higher level of reduction of adult-generated cells following MAM treatment in young and aged rats. We found only a partial reduction of adult-generated cells in the DG. More importantly, independently of the age of the animals, MAM treatment at a dose necessary to reduce neurogenesis altered the overall health of the animals. In conclusion, the behavioural results obtained following subchronic treatment with high doses of MAM in adulthood must be interpreted with extreme caution.

Original publication

DOI

10.1111/j.1460-9568.2005.04262.x

Type

Journal article

Journal

Eur J Neurosci

Publication Date

08/2005

Volume

22

Pages

778 - 783

Keywords

Age Factors, Aging, Analysis of Variance, Animals, Behavior, Animal, Body Weight, Bromodeoxyuridine, Cell Count, Cell Proliferation, Dentate Gyrus, Dose-Response Relationship, Drug, Immunohistochemistry, Ki-67 Antigen, Male, Methylazoxymethanol Acetate, Microtubule-Associated Proteins, Motor Activity, Neurons, Neuropeptides, Protein Synthesis Inhibitors, Psychomotor Performance, Rats, Rats, Sprague-Dawley, Reaction Time, Time Factors