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Genetic effects on behavioural measures thought to model anxiety have been reported on 15 mouse chromosomes. In general the individual effect from each locus is small, contributing to 10% or less of the total variation, but through use of crosses between inbred rodents the power to detect such effects is high: 39 loci have been reported at stringent levels of significance. Novel multivariate analyses of these data go some way to characterizing the genetic architecture of anxiety and also to validating the tests that are used for its measurement. However, we are still some way from finding the molecular variants that explain the heritability of the trait.

Type

Journal article

Journal

FEBS Lett

Publication Date

02/10/2002

Volume

529

Pages

131 - 134

Keywords

Animals, Anxiety, Chromosome Mapping, Disease Models, Animal, Emotions, Mice, Quantitative Trait, Heritable, Rats, Reproducibility of Results