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Due to their membrane location, G protein-coupled receptors (GPCRs) are subject to regulation by soluble and integral membrane proteins as well as membrane components, including lipids and sterols. GPCRs also undergo a variety of post-translational modifications, including palmitoylation. A recent article by Zheng et al. in BMC Cell Biology demonstrates cooperative roles for receptor palmitoylation and cholesterol binding in GPCR dimerization and G protein coupling, underlining the complex regulation of these receptors.

Original publication

DOI

10.1186/1741-7007-10-27

Type

Journal article

Journal

BMC Biol

Publication Date

19/03/2012

Volume

10

Keywords

Cell Line, Cholesterol, GTP-Binding Proteins, Humans, Lipoylation, Protein Multimerization, Protein Processing, Post-Translational, Receptors, G-Protein-Coupled, Signal Transduction