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Copolymer 1 (Cop 1, poly [Y, E, A, K]) is a random synthetic amino acid copolymer effective in the treatment of relapsing forms of multiple sclerosis (MS), a disease that is linked to HLA-DR2 (DRB1*1501). In the present study various peptides, synthesized according to the binding motifs for both the immunodominant epitope of myelin basic protein (MBP) 85-99, a candidate autoantigen in MS, and Cop 1, differentially inhibited binding of these antigens to disease-associated HLA-DR2 (DRB1*1501) molecules. In particular, two peptides with residue K at position P-1, as referred to MBP 85-99, inhibited effectively the binding of both biotinylated MBP 85-99 and Cop 1 to HLA-DR2 molecules as well as IL-2 production by two MBP-specific HLA-DR2-restricted T-cell clones. These findings suggest the possible utility of these compounds or their more stable derivatives in treatment of MS.

Type

Journal article

Journal

Hum Immunol

Publication Date

08/2001

Volume

62

Pages

753 - 763

Keywords

Antibodies, Cross Reactions, Dose-Response Relationship, Drug, HLA-DR2 Antigen, Humans, Immunodominant Epitopes, Multiple Sclerosis, Myelin Basic Protein, Peptide Fragments, Peptides, Protein Binding, T-Lymphocytes, Helper-Inducer