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Epidemiological evidence supports the existence of a possible link between type II diabetes mellitus (T2DM) and late-onset Alzheimer's disease (LOAD). Polymorphisms from candidate genes for T2DM were genotyped in a two-stage approach to identify novel risk factors for LOAD. One hundred fifty-two polymorphisms were initially genotyped in a case:control cohort: nine SNPs showed individual association with disease status under at least one genetic model, while an additional two SNPs showed a haplotype association. In a replication study, we confirmed significant association of SNPs within three genes - PPARγ, SOS2, and PCK1 - with Alzheimer's disease. In particular, our data suggest that the effect of variants within these genes might be influenced by gender. © 2007 Wiley-Liss, Inc.

Original publication

DOI

10.1002/ajmg.b.30503

Type

Journal article

Journal

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Publication Date

05/06/2007

Volume

144

Pages

508 - 516