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CAMPATH-1H is a humanised mAb directed against lymphocytes. This mAb has been used to treat patients with rheumatoid arthritis. Clinical improvement with reduction in the Ritchie index and joint score has lasted for up to 8 months in some patients. A profound and prolonged lymphopaenia is induced by the mAb, with CD4+ numbers remaining suppressed for up to one year.

Type

Conference paper

Publication Date

03/1993

Volume

11 Suppl 8

Pages

S165 - S167

Keywords

Animals, Antibodies, Monoclonal, Antigens, CD, Antigens, Neoplasm, Arthritis, Rheumatoid, Glycoproteins, Humans, Leukocyte Count, Lymphocyte Depletion, Lymphocytes, Recombinant Fusion Proteins