Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

The role of human chromosome 2 in type 1 diabetes was evaluated by analysing linkage and linkage disequilibrium at 21 microsatellite marker loci, using 348 affected sibpair families and 107 simplex families. The microsatellite D2S152 was linked to, and associated with, disease in families from three different populations. Our evidence localizes a new diabetes susceptibility gene, IDDM7, to within two centiMorgans of D2S152. This places it in a region of chromosome 2q that shows conserved synteny with the region of mouse chromosome 1 containing the murine type 1 diabetes gene, Idd5. These results demonstrate the utility of polymorphic microsatellites for linkage disequilibrium mapping of genes for complex diseases.

Original publication

DOI

10.1038/ng0195-80

Type

Journal article

Journal

Nat Genet

Publication Date

01/1995

Volume

9

Pages

80 - 85

Keywords

Adolescent, Adult, Alleles, Animals, Base Sequence, Chromosome Mapping, Chromosomes, Human, Pair 2, DNA Primers, DNA, Satellite, Diabetes Mellitus, Type 1, Female, Genetic Markers, Humans, Linkage Disequilibrium, Male, Mice, Molecular Sequence Data