Monoclonal antibody therapy of diffuse cutaneous scleroderma with CAMPATH-1H.
Isaacs JD., Hazleman BL., Chakravarty K., Grant JW., Hale G., Waldmann H.
A worker in a polyvinyl chloride factory with rapidly progressive diffuse cutaneous scleroderma was treated with the humanized monoclonal antibody (Mab) CAMPATH-1H. Treatment was followed by rapid and substantial improvement in skin score, which was maintained during followup without additional therapy. The mode of action of CAMPATH-1H and its relationship to clinical improvement are discussed.