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The widespread use of antiviral drugs against HIV has increased the prevalence of HIV-1 resistant strains among naïve individuals due to transmission of resistant strains. The purpose of this study was to investigate the presence of HIV-1 strains harboring resistance mutations in naïve patients in Greece. Blood samples were collected from 25 individuals. The DNA sequence of protease and partial reverse transcriptase regions (codons 41-223) were obtained by direct sequencing. Our results showed the absence of any primary resistance mutations in the study population. However, we were able to identify high prevalence of sequence polymorphisms at positions in reverse transcriptase region associated mainly with resistance to NNRTIs. Moreover, in protease region several secondary mutations were detected, suggesting the higher genetic variability of this region. The clinical significance of the polymorphisms associated with reduced susceptibility to NNRTIs remains to be clarified.

Type

Journal article

Journal

Virus Res

Publication Date

23/04/2002

Volume

85

Pages

109 - 115

Keywords

Amino Acid Sequence, Anti-HIV Agents, Drug Resistance, Viral, Gene Frequency, Genotype, Greece, HIV Infections, HIV Protease, HIV Reverse Transcriptase, HIV-1, Humans, Molecular Sequence Data, Mutation, Polymorphism, Genetic, Reverse Transcriptase Inhibitors