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Apolipoprotein E is the predominant brain lipoprotein and polymorphic variation in the APOE gene the major genetic susceptibly factor for late onset Alzheimer's disease (AD). Recently it was reported that carboxyl-truncated ApoE fragments induce tangle-like structures in neurons. We confirm the finding: in mouse neuroblastoma cells truncated apoE fragments lacking the carboxyterminus induce structures that have the appearance of neurofibrillary tangles. However these tangles are not induced in non-neuronal cells even in the presence of co-expressed neurofilaments or tau. Further understanding of the basis of this cell specificity might add to understanding of the cell specificity of tangles in AD.

Type

Journal article

Journal

Neuroreport

Publication Date

07/05/2002

Volume

13

Pages

867 - 870

Keywords

Alzheimer Disease, Animals, Apolipoproteins E, Brain, CHO Cells, COS Cells, Cricetinae, DNA, Complementary, Fetus, Immunohistochemistry, Inclusion Bodies, Mice, Neurofibrillary Tangles, Neurofilament Proteins, Neurons, Peptide Fragments, Protein Sorting Signals, Protein Structure, Tertiary, Transport Vesicles, Tumor Cells, Cultured, tau Proteins