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Between January 1985 and March 1992, 48 patients with chronic phase CML underwent BMT from volunteer unrelated donors (MUD) serologically identical at HLA-A, B and DR loci. 19 patients received donor marrow ex vivo T-cell depleted (EX-TCD) with Campath monoclonal antibodies. 29 patients received unmanipulated donor marrow with CsA/MTX GVHD prophylaxis; 28 received additional intravenous antilymphocyte therapy from day +1 to +5 (IN-TCD). Overall 26 patients survive at median follow up of 362 days; actuarial survival at 3 years is 50%. 3 patients have sustained haematological relapse; actuarial leukaemia-free survival is 38%. There is no difference in overall survival between the EX-TCD and IN-TCD groups, but primary graft failure (n = 4) occurred only in the EX-TCD group, while GVHD (grade II or greater) occurred more frequently in the IN-TCD group (61% vs. 29%, p = 0.084). The optimum method for GVHD prophylaxis in MUD BMT remains uncertain.

Type

Conference paper

Publication Date

1993

Volume

11 Suppl 1

Pages

107 - 111

Keywords

Adolescent, Adult, Bone Marrow Transplantation, Child, DNA, Female, HLA-A Antigens, HLA-B Antigens, HLA-DR Antigens, Humans, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Lymphocyte Depletion, Male, Middle Aged, Polymerase Chain Reaction, Retrospective Studies, T-Lymphocytes, Tissue Donors, Transplantation, Homologous, United Kingdom