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Gene-targeted mice lacking the AMPA receptor subunit GluR1 (GluR-A) have deficits in hippocampal CA3-CA1 long-term potentiation. We now report that they showed normal spatial reference learning and memory, both on the hidden platform watermaze task and on an appetitively motivated Y-maze task. In contrast, they showed a specific spatial working memory impairment during tests of non-matching to place on both the Y-maze and an elevated T-maze. In addition, successful watermaze and Y-maze reference memory performance depended on hippocampal function in both wild-type and mutant mice; bilateral hippocampal lesions profoundly impaired performance on both tasks, to a similar extent in both groups. These results suggest that different forms of hippocampus-dependent spatial memory involve different aspects of neural processing within the hippocampus.

Original publication




Journal article


Nat Neurosci

Publication Date





868 - 873


Animals, Female, Hippocampus, Long-Term Potentiation, Male, Maze Learning, Memory Disorders, Mice, Mice, Inbred C57BL, Mice, Knockout, Mutation, Neural Pathways, Neurons, Receptors, AMPA, Space Perception, Synapses, Synaptic Transmission