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Psychological traits are commonly inferred from covariation in sets of behavioral measures that otherwise appear to have little in common. Emotionality in mice is such a trait, defined here by covariation in activity and defecation in a novel environment and emergence into the open arms of an elevated plus maze. Behavioral and quantitative trait analyses were conducted on four measures obtained from 879 mice from an F2 intercross. Three loci, on murine chromosomes 1, 12, and 15, were mapped that influence emotionality. This trait, inferred from studies of strain, sex, and individual differences in rodents, may be related to human susceptibility to anxiety or neuroticism.

Type

Journal article

Journal

Science

Publication Date

08/09/1995

Volume

269

Pages

1432 - 1435

Keywords

Animals, Behavior, Animal, Chromosome Mapping, Defecation, Emotions, Female, Genes, Genetic Linkage, Genetic Variation, Lod Score, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Phenotype, Regression Analysis