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The messenger RNA processing reactions of capping, splicing, and polyadenylation occur cotranscriptionally. They not only influence one another's efficiency and specificity, but are also coordinated by transcription. The phosphorylated CTD of RNA polymerase II provides key molecular contacts with these mRNA processing reactions throughout transcriptional elongation and termination.

Type

Journal article

Journal

Cell

Publication Date

22/02/2002

Volume

108

Pages

501 - 512

Keywords

Histones, Models, Genetic, RNA Polymerase II, RNA Processing, Post-Transcriptional, RNA, Messenger, Transcription, Genetic