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Bacterial pathogens exploit a huge range of niches within their hosts. Many pathogens can invade non-phagocytic cells and survive within a membrane-bound compartment. However, only a small number of bacteria, including Listeria monocytogenes, Shigella flexneri, Burkholderia pseudomallei, Francisella tularensis and Rickettsia spp., can gain access to and proliferate within the host cell cytosol. Here, we discuss the mechanisms by which these cytosolic pathogens escape into the cytosol, obtain nutrients to replicate and subvert host immune responses.

Original publication

DOI

10.1038/nrmicro2112

Type

Journal article

Journal

Nat Rev Microbiol

Publication Date

05/2009

Volume

7

Pages

333 - 340

Keywords

Animals, Bacteria, Bacterial Physiological Phenomena, Cytosol, Humans