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The gastrointestinal tract provides a variety of environmental challenges to any bacterium seeking to successfully colonize or cause disease in a host. A major obstacle is the varied oxygen concentrations encountered at different sites in the intestine. Here we review the mechanisms bacterial pathogens utilize to sense oxygen within the gastrointestinal tract, and recent insights into how this acts as a signal to trigger virulence and to modulate host responses.

Original publication

DOI

10.1111/j.1462-5822.2010.01549.x

Type

Journal article

Journal

Cell Microbiol

Publication Date

02/2011

Volume

13

Pages

171 - 176

Keywords

Animals, Bacteria, Gastrointestinal Tract, Host-Pathogen Interactions, Humans, Immune Evasion, Oxygen, Virulence, Virulence Factors