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Embryonic stem cells (ES) cells were injected into host blastocysts either in groups of 10-15 cells or as single cells in order to test their developmental potential in the developing embryo. The analysis of midgestation chimaeras, by electrophoretic separation of glucose phosphate isomerase (GPI) isozymes, showed that ES cells were capable of colonizing trophectoderm and primitive endoderm derivatives at a low frequency, as well as producing a high rate of chimaerism in tissues of the fetus and extraembryonic mesoderm.

Type

Journal article

Journal

Development

Publication Date

04/1989

Volume

105

Pages

733 - 737

Keywords

Animals, Cell Line, Chimera, Electrophoresis, Embryo, Mammalian, Glucose-6-Phosphate Isomerase, Humans, Isoenzymes, Mice, Mice, Inbred Strains, Stem Cells