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Lambert-Eaton myasthenic syndrome (LEMS) is an immune-mediated disorder of the neuromuscular junction that rarely is associated with cerebellar ataxia (CA). We describe two patients with non-paraneoplastic LEMS associated with CA who showed high levels of anti-P/Q-type voltage-gated calcium channels antibodies in the serum and cerebrospinal fluid, and reduced CMAP with increment after brief maximum voluntary contraction in electrophysiological studies. We suggest that LEMS should be considered in the differential diagnosis of patients with CA.

Original publication

DOI

10.1016/j.jns.2008.02.004

Type

Journal article

Journal

J Neurol Sci

Publication Date

15/07/2008

Volume

270

Pages

194 - 196

Keywords

Action Potentials, Adult, Antibodies, Calcium Channels, Cerebellar Ataxia, Female, Humans, Immunoglobulins, Intravenous, Lambert-Eaton Myasthenic Syndrome, Male, Middle Aged, Muscle, Skeletal, Neural Conduction, Paraneoplastic Syndromes