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The authors studied the HLA profile of 23 white Dutch patients with muscle-specific kinase antibody-positive myasthenia gravis (MuSK Ab+ MG) and found an association with HLA-DR14-DQ5 (odds ratio 8.5; 95% CI 3.9 to 18.7; p = 4.9 x 10(-5)). Fifty-two percent of the patients carried the DR14 allele compared with 5% of the controls (p = 1.0 x 10(-8)). This association between MuSK Ab+ MG and a relatively rare HLA haplotype differs from the previously described association of early-onset acetylcholine receptor Ab+ MG with HLA-B8-DR3.

Original publication

DOI

10.1212/01.wnl.0000218159.79769.5c

Type

Journal article

Journal

Neurology

Publication Date

13/06/2006

Volume

66

Pages

1772 - 1774

Keywords

Adolescent, Adult, Aged, Child, Cohort Studies, DNA Mutational Analysis, Female, Genetic Predisposition to Disease, HLA-DR Antigens, HLA-DR Serological Subtypes, Humans, Male, Middle Aged, Mutation, Myasthenia Gravis, Netherlands, Prevalence, Receptor Protein-Tyrosine Kinases, Receptors, Cholinergic, Risk Assessment, Risk Factors, Statistics as Topic