Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The concurrence of multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) is exceedingly rare and the pathological features have not been examined extensively. Here we describe the key pathological features of a 40 year old man with pathologically confirmed concurrent MS and ALS.This is the most pathologically illustrative case of coincident MS and ALS demonstrating inflammatory and neurodegenerative features characteristic of each disease, and is the first to exhibit the presence of TDP-43 inclusions in this clinical entity. The intricate relationship between neuroinflammation and neurodegeneration in these diseases is discussed.

Original publication

DOI

10.1186/1742-2094-9-20

Type

Journal article

Journal

J Neuroinflammation

Publication Date

24/01/2012

Volume

9

Keywords

Adult, Amyotrophic Lateral Sclerosis, Brain, Cranial Nerve Diseases, DNA-Binding Proteins, Humans, Male, Multiple Sclerosis