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Ca(2+) and cAMP signalling pathways are tightly interconnected and the cellular effects mediated by the two second messengers depend strictly on reciprocal modulation. The signalling network that derives from such interplay holds the potential for expanding the information content of the signal enormously and, thus, can contribute substantially to the specificity and diversity of the response. Recent work points to interdependent Ca(2+) and cAMP oscillation patterns as a new paradigm for signal transduction.


Journal article


Trends Neurosci

Publication Date





53 - 55


Animals, Calcium, Calcium Signaling, Cyclic AMP, Models, Biological, Models, Chemical, Neurons, Second Messenger Systems, Spinal Cord, Xenopus