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We report the course of a patient with severe autoimmune neutropenia in whom only transient responses occurred with corticosteroids, antilymphocyte globulin and granulocyte-colony stimulating factor, and who was resistant to treatment with azathioprine, cyclosporin and intravenous immunoglobulin. A 10 d course of intravenous Campath-1H monoclonal resulted in a sustained haematological response. The long-lasting effect of Campath-1H may be due to its remarkable ability to induce a profound and prolonged peripheral blood T lymphopenia.

Type

Journal article

Journal

Br J Haematol

Publication Date

05/1997

Volume

97

Pages

306 - 308

Keywords

Antibodies, Monoclonal, Antibodies, Monoclonal, Humanized, Antibodies, Neoplasm, Autoimmune Diseases, Female, Humans, Infusions, Intravenous, Leukocyte Count, Middle Aged, Neutropenia