Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Immune evasion by the human immunodeficiency virus (HIV) is unexplained but may involve the mutation of viral antigens. When cytotoxic T lymphocytes engaged CD4-positive cells that were acutely infected with HIV bearing natural variant epitopes in reverse transcriptase, substantial inhibition of specific antiviral lysis was observed. Mutant viruses capable of these transactive effects could facilitate the persistence of a broad range of HIV variants in the face of an active and specific immune response.


Journal article



Publication Date





1360 - 1362


Amino Acid Sequence, Antigenic Variation, Base Sequence, CD4-Positive T-Lymphocytes, Cell Line, Cytotoxicity, Immunologic, Epitopes, HIV Antigens, HIV Reverse Transcriptase, HIV-1, HLA-B8 Antigen, Humans, Immune Tolerance, Molecular Sequence Data, RNA-Directed DNA Polymerase, Receptors, Antigen, T-Cell, T-Lymphocytes, Cytotoxic