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It has been proposed that there are strong selective pressures which have acted during the evolution of mammals to conserve the linkage of genes on the X chromosome. If so, loci that are known to be X-linked in one mammalian species should be X-linked in others. The loci for glucose-6-phosphate dehydrogenase (E.C. 1.1.1.49) and for inosinic acid pyrophosphorylase (E.C. 2.4.2.8) are known to be X-linked in a variety of mammals. The linkage of these loci to the X chromosome of the field-vole, Microtus agrestis, is indicated by the pattern of segregation of these loci in hybrid cells derived by fusion of mouse cells with vole lymphocytes.

Type

Journal article

Journal

J Cell Sci

Publication Date

01/1975

Volume

17

Pages

95 - 112

Keywords

Aminopterin, Animals, Autoradiography, Cell Fusion, Culture Media, Culture Techniques, Electrophoresis, Female, Fibroblasts, Genes, Genetic Linkage, Glucosephosphate Dehydrogenase, Hybrid Cells, Hypoxanthines, Inosine Monophosphate, Karyotyping, L Cells (Cell Line), Lymphocytes, Male, Mice, Pentosyltransferases, Rodentia, Sex Chromosomes, Thioguanine, Thymidine, Tritium