Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Ribozymes have the potential to ablate the expression of any gene in a sequence-specific manner and, therefore, may be useful as therapeutic molecules or as tools for the analysis of gene function. Although a number of reports have described ribozymes that are effective in inhibiting gene expression, few studies have attempted, systematically, to analyze the features of ribozymes that affect their potency within cells. Experimental observations suggest that emerging rules governing ribozyme potency in cells can be understood in terms of the competitive interactions between RNA-binding proteins, complementary RNAs and their internal secondary structure.

Type

Journal article

Journal

Curr Opin Biotechnol

Publication Date

02/1995

Volume

6

Pages

44 - 49

Keywords

Animals, Gene Deletion, Gene Expression, HIV, HIV Long Terminal Repeat, Humans, Promoter Regions, Genetic, RNA, RNA, Catalytic, RNA, Complementary, RNA-Binding Proteins, Virus Replication