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The pathogenesis of severe malarial disease is not yet fully understood. It is clear that host immunopathology plays a central role, and a recent paper in BMC Evolutionary Biology suggests that the ability of the parasite to stimulate interleukin-10 production is a major factor and speculates on its impact on the coevolution of host and parasite.

Original publication

DOI

10.1186/jbiol83

Type

Journal article

Journal

J Biol

Publication Date

28/08/2008

Volume

7

Keywords

Animals, Evolution, Molecular, Host-Parasite Interactions, Humans, Malaria, Plasmodium falciparum, Virulence