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We compared the extent of positive selection acting on acute and persistent strains of measles virus (MV). Far stronger positive selection was found in the fusion (F) and haemagglutinin (H) genes from subacute sclerosing panencephalitis (SSPE) compared to acute MV cases. Most of the positively selected sites identified in these surface glycoprotein genes from SSPE cases correspond to structural, functional or antigenic areas, and could not be explained by the effects of cell passaging. The correlations between selected sites and functional studies of MV are discussed in detail with reference to the maintenance of persistent infection. No positive selection was found in the matrix (M) gene from acute cases of MV and the effects of including hypermutated SSPE M gene sequences in phylogenetic inference were also explored. Finally, using H gene data, we estimated the rate of molecular evolution for SSPE strains as 3.4 x 10(-4) substitutions/site/year, which is similar to previous estimates obtained for acute strains.

Original publication

DOI

10.1099/0022-1317-83-6-1419

Type

Journal article

Journal

J Gen Virol

Publication Date

06/2002

Volume

83

Pages

1419 - 1430

Keywords

Evolution, Molecular, Hemagglutinins, Viral, Humans, Measles, Molecular Sequence Data, SSPE Virus, Selection, Genetic, Subacute Sclerosing Panencephalitis, Viral Fusion Proteins, Viral Matrix Proteins