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Our ability to harness tolerance mechanisms will have a major impact in organ transplantation if it becomes possible to minimize drug maintenance, or even wean off immunosuppressive drugs. An improved understanding of the biology of regulatory T cells will make it possible to replace current induction regimens with those favouring the vaccination and selection of T cells that prevent graft rejection. Once tolerance is established, the continuous supply of graft antigens should sustain T cell mediated regulation as the dominant mechanism preventing graft rejection.

Type

Journal article

Journal

Curr Top Microbiol Immunol

Publication Date

2005

Volume

293

Pages

249 - 264

Keywords

Animals, Antigens, Graft Rejection, Humans, Immunophenotyping, Immunosuppression, T-Lymphocytes, Tissue Donors, Transplantation Tolerance