Novel structural insights at the extracellular plant-pathogen interface

Plant pathogens represent a critical threat to global agriculture and food security, particularly under the pressures of climate change and reduced agrochemical use. Most plant pathogens initially colonize the extracellular space or apoplast and understanding the host–pathogen interactions that occur here is vital for engineering sustainable disease resistance in crops. Structural biology has played important roles in elucidating molecular mechanisms underpinning plant-pathogen interactions but only few studies have reported structures of extracellular complexes. This article highlights these resolved extracellular complexes by describing the insights gained from the solved structures of complexes consisting of CERK1-chitin, FLS2-flg22-BAK1, RXEG1-XEG1-BAK1 and PGIP2-FpPG. Finally, we discuss the potential of AI-based structure prediction platforms like AlphaFold as an alternative hypothesis generator to rapidly advance our molecular understanding of plant pathology and develop novel strategies to increase crop resilience against disease.