Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

A human IgGI antibody has been reshaped for serotherapy in humans by introducing the six hypervariable regions from the heavy- and light-chain variable domains of a rat antibody directed against human lymphocytes. The reshaped human antibody is as effective as the rat antibody in complement and is more effective in cell-mediated lysis of human lymphocytes.

Original publication

DOI

10.1038/332323a0

Type

Journal article

Journal

Nature

Publication Date

24/03/1988

Volume

332

Pages

323 - 327

Keywords

Amino Acid Sequence, Animals, Antibodies, Monoclonal, Base Sequence, Binding Sites, Antibody, Genes, Synthetic, Humans, Immunoglobulin G, Immunoglobulin Heavy Chains, Immunoglobulin Light Chains, Immunoglobulin Variable Region, Lymphocytes, Molecular Sequence Data, Rats, Recombinant Fusion Proteins, Recombinant Proteins, Species Specificity